The ingredient 'Paradoxine®' is a trademarked version of the spice Afromomum melegueta, commonly known as grains of paradise. Paradoxine is standardized for active aromatic ketones including 6-gingerol, 6-shogaol, 6-gingerdione, and a guaranteed 12.5% of the main active 6-paradol. It is botanically related to ginger and has been traditionally used to aid in digestive and GI health. The main mechanism for fat loss for grains of paradise seems to be by activation of brown adipose tissue(BAT) and whole-body energy expenditure.10 BAT is considered metabolically active fat tissue and is primarily used to regulate body temperature by dissipating energy as heat, while white adipose tissue(WAT) is mostly used for the storage of excess energy as triglycerides. There is an inverse correlation between the amount of BAT one has and total body fat.11 Paradoxine at a dose of 40mg/d was shown to increase total energy expenditure by 6% and decrease visceral fat in healthy subjects via BAT activation.12 Typical doses of Paradoxine are 40mg, 2-3x a day.
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